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The TRUTH about NOXPLODE - CASE OPEN A skeptical view - Bodybuilding.com Forums Free Gift!Any Order Over Discounts & Deals - Sign Up!The World’s #1 Bodybuilding And Fitness Forum - Save Up To 50% Off Retail Prices In Our Bodybuilding.com Store!Iv done a bit of research on this product and am trying to weigh up all the facts, opinions, literature, studys and peoples experiences of this product.

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Im sceptical about sports supplements which have no scientific evidence to support the supplement companys (money makers) claims.I am yet to test NoXplode and am not cynical or here to bag no explode.So far this is what I have found, firstly some quotes.Sorry cant give cedit to the person who wrote them because i just cut and pasted."its advertised as a cell volumizer when in fact it only has 2grams of creatine in the form of dicreatine malate not cee.

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inmate searchAnd 2 grams of aakg.People are just taking xplode and acting like its giving them some sort of amazing pump when in fact if your not already supping with creatine and arginine thats far from likley.This is great marketing by bsn." "Yeah those 2 grams of arginine and creatine in xplode really volumize those muscles.Dont fall for the advertising beacuse 2 grams is all you get from 2 scoops of xplode.
It would take 2 scoops a day for over 60 days to saturate your muscles with xplode.
And beacuse of the caffine 2 grams of arginine is going to do nothing.Arginine is a vasodilator while caffine is a vasoconstricter.
A much higher dose of arginine is needed when taking caffine." ------------------------------------------------------------------------- Here is one study I did find on arginine and NO -------------------------------------------------------------------------- This specific product had several studies performed on it, and they were presented at the International Society of Sports Nutrition conference in the summer of 2004.
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Start of the list

While the findings do not yet come from peer reviewed publications, they yield important information about the efficacy, or lack thereof, of this supplement.

The first study examined the blood levels of arginine and "time released arginine" (following a four gram supplementation with each) to determine whether the latter enhanced the duration of elevated blood arginine levels (18).GDC city in kansas supplier weedmat.
The reasoning for this study is due to the claim that NO2 has time-release technology, resulting in "perpetual pumps.
" Unfortunately for the company, blood arginine levels were nearly all quite similar, and at times 30% lower, in the time-release trial compared to the pure arginine trial!
The reason for the lower levels of the former group remains elusive, but could be due to a decreased absorption by the gut, an increased uptake by tissues, or a half dozen other fates for arginine (see 4).
Not surprisingly, there was nothing resembling a "time release" effect.
The second study of interest evaluated the effects of NO2 on body composition, muscle strength and endurance (8).
For eight weeks, subjects took either 12 grams of NO2 or placebo and underwent a resistance training protocol.
At the end of the time period, subjects between groups had no differences in either muscle mass or body fat percentage.
Interestingly, the NO2 group threw an average of 19 pounds onto their bench 1RM, while the placebo group added less than a six pound mean.
Does it seem strange to anyone else that this supplement alone supposedly added an average of more than 13 pounds to bench press 1RM over placebo without a concomitant change in muscle mass?
This would indicate that the changes are strictly neural in origin, which gets quite complicated and goes beyond the scope of this article.
I'll briefly mention that while nitric oxide itself can have a negative effect on the force of muscle contraction (25), this effect has yet to be shown in humans, and doesn’t warrant serious consideration for our purposes.
More importantly, all of the scientific evidence indicates that it's not even possible for us to consume high enough levels of arginine to effectively increase nitric oxide levels!
Since this unpublished study is already gracing the advertisements for this supplement, we need to examine the results in a little more detail.
If the subjects in the above study were untrained, they would all add a significant amount of strength without changes in muscle mass within the first several weeks of working out.
In this case, these rapid neural adaptations would be expected in both groups, but wouldn't explain how arginine seemingly tripled the improvement in the nervous system activation.
However, since the subjects were in fact trained, the situation is even more puzzling.
Unlike novice trainees, strength increases in trained individuals tend to be more a result of muscle growth, which means that there should've been some changes in lean body mass accompanying the other gains.
There wasn't.I would've been impressed, albeit skeptical, by a three or four pound gain over the placebo group on bench press 1RM, but an average of 13 pounds?!
Looking at it another way, this means an average gain of two and a half pounds on bench 1RM each week, and this progress is maintained for a whole eight weeks on the same program!
If this trend continued for all exercises, which it presumably does, everyone with these results could easily become a competitive powerlifter.
Although such improvements might be theoretically possible, you must remember that these fantastic results were achieved on a training program and diet that normally leads to a mere six pound addition to bench press.
Furthermore, to have such incredible strength gains throughout every muscle group, without even the slightest trend for improved muscle growth, demands questioning.
Considering the other research which showed no effect on blood flow and no time release effect, the results just don’t fit.
Whether it be improper group selection, outliers in the data, or measurement error, the results presented remain questionable.
With my objective experience as a strength coach, researcher and bodybuilder, I don't believe these results to be possible.
Having said that, this article is merely intended to give you the facts that you won’t get anywhere else, and allow you make up your own mind.
Let’s sum of the results of this study and others: • One group used oral arginine in this study, but oral arginine supplementation doesn't affect blood flow.
• The arginine group used "time release" arginine, but so-called time release arginine is not actually time released.
• The trained individuals in the NO2 group got stronger without increasing muscle growth, but trained individuals get stronger mostly due to muscle growth.
• The training program and diet alone yielded a six pound increase in bench 1RM, yet four grams of NO2 taken three times a day tripled strength gains on the same program.
In short, something just isn't right.On the positive side ------------------------------------------------------------------------- Muscle Enhancing Hemodialator -Effects and Side Effects Whenever I go to the gym and tell a friend that I've recently started the supplement, Nitric Oxide, nobody knows what I'm talking about but I even mention Creatine, and that is well known as a standard for building muscle.
Could Nitric Oxide type supplements be the next Creatine?When Creatine was launched, it was expensive.
But it worked.It was a huge craze at the gyms and most everybody wanted it.
The reason they wanted it so much, is that it worked.It was legal and the side-effects, well so far, there aren't any (as long as you drink plenty of fluids).
Since the launching of this successful product, there has never been anything that hit the market with the same enthusiasm.
Nitric Oxide, according to research , "the first of an exciting new category of muscle-enhancers known as a hemodilators.
NO2 has the unique ability to perpetually sustain the flow of muscle-building agents to skeletal muscle.
" -Source: GetNO2 Before I give my review, I'd like to share another quote of the benefits and claims.
"By increasing nitric oxide production, NO2 increases your maximum contractile velocity - in all muscle types.
The results are immediate and consequential, and include increasing your load capacity, boosting your power output, and quickening your muscle contraction.
" -Source: GetNO2 When I first was asked to try this product, I was sceptical.
I've been bodybuilding for 16 years now (mainly for general fitness not to get freaky huge), and I've tried a lot of supplements.
The last time I was excited about a supplement was Creatine like most of the gym-rats.
But I'm always willing to review something and try it for myself in hopes that maybe I'll find that gem and tell the rest of the world.
Taking 3 pills before breakfast, and another 3 one-half hour before lunch, I can honestly say that while I've noticed no gains in strength yet, my muscle do feel perpetually pumped.
It's like I just came back from the gym but it lasts all day.While I cannot say the results are amazing, I can say the effects - both physical and psychological - are extraordinary.
As with any supplement, you need to drink plenty of water.Most Nitric Oxide supplements usually do not have this specific requirement, but I've noticed that being properly hydrated has helped me keep that pump going all day.
I've also seen some recommendations that taking Nitric Oxide with Creatine gives a complementary effect.
To date, I have not tried this.NO2 Side Effects I've taken this product several times and I've experience no side effects.
Does that mean there are no NO2 side effects?Truthfully, at the time of this web article, I cannot say.
Where's the research?The long term studies?Just because one person takes NO2 and experiences no side effects, doesn't mean it's a fact.
But the fact is, I've taken several brands and either experienced no effects but certainly I've not experienced any negative NO2 side effects of any kind.
While some claim that this supplement to be just more marketing bull with no research to back the claims Nitric Oxide is making, I don't know what to tell you.
It seems to be working for me.Maybe it's a placebo.But as we know.
it really doesn't matter much as long as there are no side effects and it gets results (even if those results come from a psychological factor).
Give a man a sugar pill and if he benches 405lb, who cares.
--------------------------------------------------------------------- IMO this article is truthful but bias.
Why, because they link to the purchasing of NO products.They have finacial motives.
Heres another article slaming NO.------------------------------------------------------------------------- Don't waste your money on the supplement industry's newest hype product.
It's a waste of money and unsafe.Here's a good article I found which has valid sources.
If you want a good pump in gym have a balance of good carbs like brown rice and oats and train hard.
"Nitric oxide supplements are the hottest thing on the market.
Athletes are buying them in droves without knowing exactly what is happening in the body.
Supplement companies claim to educate their consumers with pamphlets and informational websites, but these only offer an incomplete story of what is actually happening.
Manufacturers state that nitric oxide supplements, via the compound arginine alpha-ketoglutarate, gives the athlete added energy, mental focus, workout intensity, perpetual pump and muscle growth.
Upon closer investigation, these effects are largely exaggerated and in some cases completely fallacious.
While arginine is involved in the regulation of growth hormone release, the supplemental dosages that would stimulate a noticeable effect are astronomical.
Arginine is also a substrate for nitric oxide; an effect that is enhanced when combined with alpha-ketoglutarate.
Nitric oxide is released by the walls of the blood vessels that cause a decrease in the resistance and an increase in blood flow to the skeletal muscles.
Arginine may also stimulate the release of epinephrine from the adrenal gland.
These two effects are mostly beneficial to endurance athletes, not strength athletes like the manufacturers suggest.
Grasemann et al.(2005) determined that participants receiving as little as 200 mg of L-arginine showed a significant increase in nitric oxide formation, as well as significant increases in plasma L-arginine and sputum L-arginine.
This indicates that L-arginine supplementation does indeed induce nitric oxide formation.
Rytlewski et al.(2005) found that three weeks of L-arginine supplementation lead to significant drops in systolic blood pressure, diastolic blood pressure, and mean arteriole pressure while elevating urinary excretion of NOx (nitrates) and mean plasma levels of l-citrulline.
However, plasma L-arginine levels were not effected even with 300 mg of supplementation.
Thusfar it has been established that L-arginine supplementation does indeed stimulate nitric oxide synthesis.
Now it must be addressed whether or not this is beneficial to athletes.
Paddon-Jones et al.(2004) found that nitric oxide supplementation does not provide an ergogenic effect to healthy individuals.
Miguez et al.(2004) found that 4 weeks of L-arginine supplementation increased serum triglyceride levels and significantly increased levels of low-density lipoprotein (LD) cholesterol.
This is obviously cause for concern and needs to be further investigated.
Evans et al.(2004) sought to find the optimal dosage of L-arginine to elicit the greatest effect on nitric oxide synthesis.
Manufacturers recommend upwards of 6000-10000 mg/day but many athletes report taking even higher dosages as much as 35000 mg/day, nearly six times the recommended intake.
Evans (2004) found that half the participants supplementing with 20000 mg/day reported serious adverse side effects from L-arginine supplementation and over half of the participants reported severe side effects when taking more than 20000 mg/day.
A significant portion of individuals supplementing with 9000 mg/day reported adverse effects, and over the duration of the supplementation period, no participants experienced any sort of weight gain.
Chu et al.(2004) found that L-arginine supplementation impaired pulmonary endothelium-dependent relaxation of vascular tissue.
This may lead to potentially dangerous vascular spasms and cardiovascular abnormalities.
It has been found that L-arginine keto-gluterate supplementation stimulates rapid vasidilation in a non-discriminatory fashion.
Significant vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops).
Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, significant drop in both systolic and diastolic blood pressure.
During exercise, it is imperative that diastolic blood pressure remain constant.
It is natural for systolic blood pressure to rise during the onset of exercise, but diastolic blood pressure values must remain constant.
A drop in either during exercise is cause for great concern and can lead to serious cardiovascular damage.
In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels leading to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little).
This is a dangerous sequence that can potentially lead to a vascular catastrophe.
Based on the available research, this author strongly recommends that athletes avoid nitric oxide and hemodilator supplements in the interest of safety.
Moreover, it has been suggested that these supplements have little or no anabolic or ergogenic benefits for the athlete.
" Want more....ok ------------------------------------------------------------------------- The price has come down on NO2 supplements.
There's still little to no actual research.I've still experienced no NO2 side effects.
And I've found a few products to be ineffective and give me no pumps, no results and others, I feel a lot stronger.
Depends on what you want...If you want an hour long pump then go ahead because that's all it's good for.
Nitric Oxide – what is it?Nitric oxide is a colorless, free radical gas commonly found in tissues of all mammals (it’s also prepared commercially by passing air through an electric arc).
Biologically, nitric oxide has been shown to be an important neuro-messenger in a number of vertebrate signal transduction processes.
Nitric oxide is used in medical treatment; for example, nitroglycerin ameliorates the pain of angina by supplying nitric oxide to the blood vessels that supply the heart.
The popular drug Viagra controls erection by regulating nitric oxide in the penile cartilage chamber.
The Research and the Claims I don’t know where the marketers obtained their literature on nitric oxide.
It looks like they are using the same journals as the companies selling Myostatin inhibitors – Alice in Wonderland.
Although nitric oxide acts as a cell-to-cell communicator for certain metabolic functions, muscle growth is not one of them.
After a review of the available literature I cannot find any research that remotely indicates increasing nitric oxide levels plays a part in increasing protein synthesis, contractile strength or any other biochemical pathway that may lead to increases in muscle mass.
For a company to claim their supplement increases “fast-twitch” muscle strength, the promoters must have instigated or funded some kind of research that involved biopsy procedures and histochemical analyses to extract, assesses and identify these particular muscle fibers from animals or humans, before and after supplementation.
However, I could find no documentation (either on their web sites or via a literature scan) that details these findings, only the marketing claims.
As far as I’m aware, there is zero scientific evidence supporting the notion that nitric oxide supplements increase “fast-twitch” muscle strength.
There also appears to be no evidence whatsoever that shows increasing nitric oxide levels enhances endurance, power output, and load capacity.
Arginine alpha-ketogluterate is the “active” ingredient reported by one company that sells this type of supplement.
It is claimed that this compound increases and maintains a constantly high level of nitric oxide in muscle.
Nitric oxide is synthesized within the body using the amino acid arginine, the energy cyclic substrate NADPH, and oxygen.
Nitric oxide diffuses freely across membranes but it is a transient signaling molecule.
Nitric oxide is by nature, a highly reactive gas that has an extremely short life – less than a few seconds.
While there is a lot of research on the effects of nitric oxide, there is no research that shows supplementation with arginine alpha-ketogluterate increases or sustains nitric oxide levels in any human or animal organs.
Can you imagine, a supplement that “creates dramatic increases in muscle size, strength, endurance, power output, and load capacity”, but not a single study to support these claims.
Nothing new here.Unfortunately, this is typical sports nutrition marketing bull****.
It's sad, misleading, and shows you just what these companies think of the intelligence level of their target market.
When new products burst onto the market, you the consumer can cut through the advertising hype quite easily.
Simply ask the supplement company making the claims to "show you the research".
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A reference is a start, but the actual research study is particularly what your after.
You want to see the study, the protocol, the outcome and the University at which the study was conducted.
In the present case, you want to see a study showing were this supplement actually increased nitric oxide above a control group, and you want to see the data that demonstrates an increase in lean muscle mass, significantly more than the group without elevated nitric oxide levels.
The fact is, there is no science supporting any of the claims made for so-called nitric oxide supplements.
There is no science showing they have any effect on nitric oxide levels and certainly no science showing in effects on muscle growth or increased performance.
Ask yourself why there is no research to support these companies’ wild claims.
The simple answer is that research is expensive, make believe products are not.
Research provides evidence, fraudulent supplement marketing only delivers hype.
It’s far more financially rewarding to sell hype than to produce effective supplements backed by science.
One promoter of a nitric oxide supplement claims to have “brought creatine supplementation to the market” and that their supplement is “the perfected version of creatine”.
I’m not sure which market is being referred to but creatine has been used as a supplement for over 40 years.
And in NO way are nitric oxide supplements a “perfected version of creatine”.
They are nothing like creatine.While creatine is backed by a wealth of research, nitric oxide supplements do not have a shred of scientific evidence that justifies their effectiveness as a bodybuilding supplements.
Bottom line, money spent on these products is money flushed down the toilet.
Read the Real Science 1.Nathan C.Nitric oxide as a secretory product of mammalian cells.
FASEB J 1992 6(12):3051-64.2.Mayer B; Hemmens B.Biosynthesis and action of nitric oxide in mammalian cells.
Trends Biochem Sci 1997 22(12):477-81.3.Janabi N; Chabrier S; Tardieu M.
Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide, and superoxide anion (O2-) regulatory pathways.
J Immunol 1996 1;157(5):2129-35.4.Esposito C; Cozzolino A; Porta R; Mariniello L; Buommino E; Morelli F; Metafora V; Metafora S.
Protein SV-IV promotes nitric oxide production not associated with apoptosis in murine macrophages.
Eur J Cell Biol 2002 81(4):185-96.5.Eckmann L; Laurent F; Langford TD; Hetsko ML; Smith JR; Kagnoff MF; Gillin FD.
Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia.
J Immunol 2000 1;164(3):1478-87.6.Kelly RA; Smith TW.Nitric oxide and nitrovasodilators: similarities, differences, and interactions.
Am J Cardiol 1996 30;77(13):2C-7C.7.Stryer L.Biochemistry 4th Ed.
Freeman & Co.1997.The Real Secret Here’s where things get real interesting.
You may want to be seated for this, because I’m about to blow the lid off the whole deal.
Arginine is the amino acid known to be the most potent insulin secretagogue, meaning that it causes insulin release from the pancreas (4).
Now this is of critical importance, because insulin itself stimulates vasodilation and blood flow (2), and this occurs via elevations in nitric oxide synthesis (27).
So arginine stimulates insulin, and insulin stimulates nitric oxide.Nitric oxide causes vasodilation and increased blood flow.
Hmmm Combining this info with what the scientific literature tells us, we can see that much of arginine’s vasodilatory effect can be attributed to insulin secretion!
In fact, one study examined the extent of this very effect, and the results are shocking.
Researchers infused the standard 30 grams of arginine with or without blocking insulin release from the pancreas (15).
As usual, the massive arginine infusion increased blood flow.But, when insulin release was blocked, blood flow decreased by 77%!
When the latter experiment was repeated with an insulin infusion, blood flow was completely restored!
So, over three-quarters of the increased blood flow response was caused by insulin.
While not all arginine-induced blood flow can be attributed to insulin, you must remember that these studies use the equivalent of over 40 grams orally ingested arginine, which isn't even possible to tolerate.
The Revised Theory: Arginine -> Insulin -> Nitric Oxide -> Vasodilation -> Nutrient Delivery -> Muscle Growth and Strength You have to wonder if the companies who produce these supplements knew this when they began to market them.
If they did, then they intentionally swindled people.If they didn’t, then they clearly didn’t have any idea what they were asking people to put into their bodies.
Either way, it’s lose-lose for them.To make things worse, AKG is being shown to play a role in stimulating insulin secretion (23), suggesting that companies may have indeed been trying to pull the wool over our eyes the whole time.
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While this addition may seem beneficial, you have to remember that we still have no real evidence even suggesting that any of these products work at reasonable doses.And don't forget, an increase in insulin levels (and therefore blood flow) is all too easy to obtain without NO products.Why would we use arginine to stimulate blood flow when we can get direct effects by manipulating insulin?In Part II of this article, I'll tell you how to do that without arginine supplements.The good news is, you're probably already doing it!

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